By adapting the colour temperature for the time of the day it will make your screen more viewable and it is good for your eyes.
f.lux makes your computer screen look like the room you're in, all the time. When the sun sets, it makes your computer look like your indoor lights. In the morning, it makes things look like sunlight again.
Tell f.lux what kind of lighting you have, and where you live. Then forget about it. F.lux will do the rest, automatically.